The criteria for defining CR, with or without minimal residual disease recently changed. Bone marrow biopsy should be delayed four to 6 months after cladribine administration and performed after a clinical response with pentostatin therapy. The first patient's profile is that of an aggressive and multiply refractory disease, and the second is of a more indolent disease that responded very well to splenectomy.

The HCL score at 2 is also consistent with this diagnosis. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username

Cas no 2. A disintegrin and metalloproteinase with thrombospondin motifs type 4 (ADAMTS-4) is an extracellular protease capable of degrading CSPGs. View Françoise Ledos’ profile on LinkedIn, the world's largest professional community. Unable to load your collection due to an error 3 Normandie Univ, UNICAEN, ISTS, 14000 Caen, France.

Normandie Université, INSERM U1245, Université de Caen, Caen, France Electronic address: brossier-d@chu-caen.fr.

The morphology of the lymphocytes in these two patients suggests the diagnosis of vHCL, particularly the presence of a net nucleolus and fine and circumferential villi. 2020 Mar 5;10(3):403. doi: 10.3390/biom10030403.Luo F, Tran AP, Xin L, Sanapala C, Lang BT, Silver J, Yang Y.Nat Commun.

D, Complete blood count evolution. The number of cases of vHCL reported in the literature is still low because of the rarity of this hematologic disorder.

E-mail address: troussard-x@chu-caen.fr Laboratoire d’Hématologie, CHU Caen, Caen, France. The thoracoabdominopelvic CT showed a heterogeneous spleen of 23 cm. Interferon alpha (IFN) can be also an alternative in pregnant women.All the published data suggest there is no long‐term follow‐up showing a plateau in failure‐free survival.

Gray areas do exist and variants of typical HCL should be discussed in a few cases, particularly HCL‐V, SDRPL or positive or negative Please check your email for instructions on resetting your password.

Despite a short follow‐up period in the case of the first patient, the initial response to treatment remains satisfactory.

Normandie Université, INSERM U1245, Université de Caen, Caen, FranceNormandie Université, INSERM U1245, Université de Caen, Caen, FranceNormandie Université, INSERM U1245, Université de Caen, Caen, FranceInstitut d'Hématologie de Basse‐Normandie, CHU Caen, Caen, FranceXavier Troussard, Laboratoire d’Hématologie, Institut d’Hématologie de Basse‐Normandie, CHU Caen, Caen, France.Normandie Université, INSERM U1245, Université de Caen, Caen, FranceNormandie Université, INSERM U1245, Université de Caen, Caen, FranceNormandie Université, INSERM U1245, Université de Caen, Caen, FranceInstitut d'Hématologie de Basse‐Normandie, CHU Caen, Caen, FranceXavier Troussard, Laboratoire d’Hématologie, Institut d’Hématologie de Basse‐Normandie, CHU Caen, Caen, France.Use the link below to share a full-text version of this article with your friends and colleagues.

INTRODUCTION: Apnea is commonly encountered in children with bronchiolitis.